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Striving Towards the Perfect In Vitro Oral Drug Absorption Model.

Authors :
Gleeson JP
McCartney F
Source :
Trends in pharmacological sciences [Trends Pharmacol Sci] 2019 Oct; Vol. 40 (10), pp. 720-724. Date of Electronic Publication: 2019 Aug 16.
Publication Year :
2019

Abstract

Oral drug delivery systems have multiple goals, assessing and enabling intestinal absorption at efficacious doses being one of them. Here we highlight the in vitro advances in modeling drug absorption, which more faithfully reflect human intestinal physiology and reduce the reliance on animal models.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Subjects

Subjects :
Administration, Oral
Animals
Caco-2 Cells
Humans
In Vitro Techniques
Intestinal Absorption
Models, Animal
Organoids metabolism
Tissue Engineering methods
Intestinal Mucosa metabolism
Pharmaceutical Preparations administration & dosage
Pharmaceutical Preparations metabolism
Pharmacokinetics

Details

Language :
English
ISSN :
1873-3735
Volume :
40
Issue :
10
Database :
MEDLINE
Journal :
Trends in pharmacological sciences
Publication Type :
Academic Journal
Accession number :
31422894
Full Text :
https://doi.org/10.1016/j.tips.2019.07.010
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