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Determinants of diagnostic discordance for non-diabetic hyperglycaemia and Type 2 diabetes using paired glycated haemoglobin measurements in a large English primary care population: cross-sectional study.
- Source :
-
Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2019 Nov; Vol. 36 (11), pp. 1478-1486. Date of Electronic Publication: 2019 Sep 03. - Publication Year :
- 2019
-
Abstract
- Aim: To investigate factors influencing diagnostic discordance for non-diabetic hyperglycaemia and Type 2 diabetes.<br />Methods: Some 10 000 adults at increased risk of diabetes were screened with HbA <subscript>1c</subscript> and fasting plasma glucose (FPG). The 2208 participants with initial HbA <subscript>1c</subscript> ≥ 42 mmol/mol (≥ 6.0%) or FPG ≥ 6.1 mmol/l were retested after a median 40 days. We compared the first and second HbA <subscript>1c</subscript> results, and consequent diagnoses of non-diabetic hyperglycaemia and Type 2 diabetes, and investigated predictors of discordant diagnoses.<br />Results: Of 1463 participants with non-diabetic hyperglycaemia and 394 with Type 2 diabetes on first testing, 28.4% and 21.1% respectively had discordant diagnoses on repeated testing. Initial diagnosis of non-diabetic hyperglycaemia and/or impaired fasting glucose according to both HbA <subscript>1c</subscript> and FPG criteria, or to FPG only, made reclassification as Type 2 diabetes more likely than initial classification according to HbA <subscript>1c</subscript> alone. Initial diagnosis of Type 2 diabetes according to both HbA <subscript>1c</subscript> and FPG criteria made reclassification much less likely than initial classification according to HbA <subscript>1c</subscript> alone. Age, and anthropometric and biological measurements independently but inconsistently predicted discordant diagnoses and changes in HbA <subscript>1c</subscript> .<br />Conclusions: Diagnosis of non-diabetic hyperglycaemia or Type 2 diabetes with a single measurement of HbA <subscript>1c</subscript> in a screening programme for entry to diabetes prevention trials is unreliable. Diagnosis of non-diabetic hyperglycaemia and Type 2 diabetes should be confirmed by repeat testing. FPG results could help prioritise retesting. These findings do not apply to people classified as normal on a single test, who were not retested.<br /> (© 2019 Diabetes UK.)
- Subjects :
- Aged
Blood Glucose metabolism
Cross-Sectional Studies
Diabetes Mellitus, Type 2 epidemiology
Diabetes Mellitus, Type 2 physiopathology
Diabetes Mellitus, Type 2 prevention & control
Disease Progression
England epidemiology
Female
Glucose Tolerance Test
Humans
Hyperglycemia epidemiology
Hyperglycemia physiopathology
Male
Middle Aged
Prediabetic State epidemiology
Prediabetic State physiopathology
Primary Health Care
Reproducibility of Results
Diabetes Mellitus, Type 2 blood
Fasting blood
Glycated Hemoglobin metabolism
Hyperglycemia blood
Mass Screening
Prediabetic State blood
Subjects
Details
- Language :
- English
- ISSN :
- 1464-5491
- Volume :
- 36
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Diabetic medicine : a journal of the British Diabetic Association
- Publication Type :
- Academic Journal
- Accession number :
- 31420897
- Full Text :
- https://doi.org/10.1111/dme.14111