Back to Search
Start Over
[False paraprotein-induced hypoglycemia in the measurement of glucose by the hexokinase method].
- Source :
-
Annales de biologie clinique [Ann Biol Clin (Paris)] 2019 Aug 01; Vol. 77 (4), pp. 439-445. - Publication Year :
- 2019
-
Abstract
- A 67 years old woman with a Waldenström disease was admitted in the intensive care unit for dyspnea and fever. During hospitalization, episodes of undetectable glycemia were observed without any hypoglycemia symptoms. Plasma glucose was determined with the hexokinase method (recommended). From this observation, a literature review on PubMed was performed to investigate similar cases. In patients with protides in excess (e.g. immunoproliferative syndrome), absorption measurements could be disrupted by the precipitation of excess protein (IgM in most cases). Other parameters could be affected: bilirubin, phosphate, HDL cholesterol, GGT, CRP and calcemia. In our case, the main difficulty was to identify the cause of the interference and then correct it. Using a series of dilution, we prevented protide precipitation allowing correct glucose determination. Those interferences are rare, but present a real analytical difficulty. Biologists should be aware of those interferences because of dramatics consequences.
- Subjects :
- Aged
Artifacts
Blood Chemical Analysis standards
Blood Glucose metabolism
Diagnosis, Differential
Dyspnea blood
Dyspnea diagnosis
Dyspnea etiology
False Positive Reactions
Female
Fever blood
Fever diagnosis
Fever etiology
Hexokinase chemistry
Humans
Hypoglycemia blood
Paraproteins metabolism
Retinal Hemorrhage blood
Retinal Hemorrhage diagnosis
Retinal Hemorrhage etiology
Waldenstrom Macroglobulinemia complications
Waldenstrom Macroglobulinemia diagnosis
Blood Chemical Analysis methods
Blood Glucose analysis
Hexokinase metabolism
Hypoglycemia diagnosis
Paraproteins adverse effects
Waldenstrom Macroglobulinemia blood
Subjects
Details
- Language :
- French
- ISSN :
- 1950-6112
- Volume :
- 77
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annales de biologie clinique
- Publication Type :
- Academic Journal
- Accession number :
- 31418706
- Full Text :
- https://doi.org/10.1684/abc.2019.1465