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Combination Treatment with Rituximab and Bortezomib in a Patient with Non-Paraneoplastic Autoimmune Retinopathy.
- Source :
-
Ocular immunology and inflammation [Ocul Immunol Inflamm] 2020 Aug 17; Vol. 28 (6), pp. 958-965. Date of Electronic Publication: 2019 Aug 16. - Publication Year :
- 2020
-
Abstract
- Purpose: To describe outcomes of combined rituximab and bortezomib treatment for non-paraneoplastic autoimmune retinopathy.<br />Case: A 37-year-old female developed photopsias and reduced vision. Electroretinography, optical coherence tomography, and positive serum anti-retinal antibodies were consistent with autoimmune retinopathy. A negative malignancy work-up specified her non-paraneoplastic presentation. Given absence of response to periocular steroids, azathioprine, and methotrexate, a combination of rituximab and bortezomib was initiated as fifth-line therapy.<br />Results: There was no significant improvement in the patient's symptoms or visual function following treatment. The full field electroretinogram amplitudes were reduced with progressive outer retinal degeneration evident on optical coherence tomography. Post-treatment anti-retinal antibody testing demonstrated the persistence of antibodies and revealed additional antibodies not previously detected.<br />Conclusion: Combined rituximab and bortezomib treatment did not result in significant clinical improvement and there was evidence of disease progression. Further prospective studies are required to assess the efficacy of immunotherapy in patients with autoimmune retinopathy.
- Subjects :
- Adult
Autoimmune Diseases immunology
Drug Therapy, Combination
Electroretinography
Female
Humans
Paraneoplastic Syndromes drug therapy
Paraneoplastic Syndromes immunology
Prospective Studies
Retinal Diseases immunology
Tomography, Optical Coherence
Visual Field Tests
Visual Fields
Autoantibodies blood
Autoimmune Diseases drug therapy
Bortezomib therapeutic use
Immunologic Factors therapeutic use
Retina immunology
Retinal Diseases drug therapy
Rituximab therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5078
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Ocular immunology and inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 31418623
- Full Text :
- https://doi.org/10.1080/09273948.2019.1636094