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Impact of Zika Virus Emergence in French Guiana: A Large General Population Seroprevalence Survey.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2019 Nov 06; Vol. 220 (12), pp. 1915-1925. - Publication Year :
- 2019
-
Abstract
- Background: Since the identification of Zika virus (ZIKV) in Brazil in May 2015, the virus has spread throughout the Americas. However, ZIKV burden in the general population in affected countries remains unknown.<br />Methods: We conducted a general population survey in the different communities of French Guiana through individual interviews and serologic survey during June-October 2017. All serum samples were tested for anti-ZIKV immunoglobulin G antibodies using a recombinant antigen-based SGERPAxMap microsphere immunoassay, and some of them were further evaluated through anti-ZIKV microneutralization tests.<br />Results: The overall seroprevalence was estimated at 23.3% (95% confidence interval [CI], 20.9%-25.9%) among 2697 participants, varying from 0% to 45.6% according to municipalities. ZIKV circulated in a large majority of French Guiana but not in the most isolated forest areas. The proportion of reported symptomatic Zika infection was estimated at 25.5% (95% CI, 20.3%-31.4%) in individuals who tested positive for ZIKV.<br />Conclusions: This study described a large-scale representative ZIKV seroprevalence study in South America from the recent 2015-2016 Zika epidemic. Our findings reveal that the majority of the population remains susceptible to ZIKV, which could potentially allow future reintroductions of the virus.<br /> (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Communicable Diseases, Emerging diagnosis
Communicable Diseases, Emerging immunology
Cross-Sectional Studies
Female
French Guiana epidemiology
Geography, Medical
Humans
Male
Middle Aged
Population Surveillance
Seroepidemiologic Studies
Serologic Tests
Young Adult
Zika Virus Infection diagnosis
Zika Virus Infection immunology
Communicable Diseases, Emerging epidemiology
Communicable Diseases, Emerging virology
Zika Virus immunology
Zika Virus Infection epidemiology
Zika Virus Infection virology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 220
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31418012
- Full Text :
- https://doi.org/10.1093/infdis/jiz396