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Interplay of protein corona and immune cells controls blood residency of liposomes.
- Source :
-
Nature communications [Nat Commun] 2019 Aug 15; Vol. 10 (1), pp. 3686. Date of Electronic Publication: 2019 Aug 15. - Publication Year :
- 2019
-
Abstract
- In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological identity' due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes' synthetic identity. The liposome-protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.
- Subjects :
- Adsorption
Blood Proteins immunology
Blood Proteins metabolism
Chromatography, High Pressure Liquid
Flow Cytometry
Humans
Leukocytes immunology
Liposomes metabolism
Liposomes ultrastructure
Microscopy, Electron, Transmission
Protein Corona metabolism
Spectrometry, Mass, Electrospray Ionization
THP-1 Cells
Leukocytes, Mononuclear immunology
Liposomes blood
Liposomes immunology
Protein Corona immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 31417080
- Full Text :
- https://doi.org/10.1038/s41467-019-11642-7