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[Viral latency of HIV-1].
- Source :
-
Virologie (Montrouge, France) [Virologie (Montrouge)] 2019 Aug 01; Vol. 23 (4), pp. 195-210. - Publication Year :
- 2019
-
Abstract
- Human immunodeficiency virus (HIV-1) latency is clinically highlighting via the persistence of a residual viral load in cART-treated patients due to the reactivation of cellular reservoirs. Two forms of latency coexist but the contribution of the pre-integrationnal latency clearly plays a minor role in viral persistence. In contrast, the post-integrationnal latency significantly contributes to the evasion of the immune system by the HIV-1 cellular reservoir and consequently to HIV-1 pathogenesis. Although post-transcriptional mechanisms can contribute to the maintenance of viral latency, HIV-1 transcriptional inhibition is critical for the establishment and maintenance of post-integrational latency. This inhibition is a multifactorial phenomenon, making the development of anti-latency therapeutic strategies complex. These different notions will be described throughout this review.
- Subjects :
- CD4-Positive T-Lymphocytes virology
Chromatin Assembly and Disassembly
DNA Methylation
Disease Reservoirs virology
HIV Infections immunology
HIV-1 genetics
Histone Code
Humans
Immune Evasion
Immunologic Memory
Macrophages virology
Monocytes virology
Nucleosomes ultrastructure
Proviruses physiology
Signal Transduction
Transcription Factors physiology
Transcription, Genetic
Viral Load
Virus Activation
Virus Integration
tat Gene Products, Human Immunodeficiency Virus physiology
HIV Infections virology
HIV-1 physiology
Virus Latency physiology
Subjects
Details
- Language :
- French
- ISSN :
- 1267-8694
- Volume :
- 23
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Virologie (Montrouge, France)
- Publication Type :
- Academic Journal
- Accession number :
- 31414658
- Full Text :
- https://doi.org/10.1684/vir.2019.0782