Back to Search Start Over

Propofol Formulation Affects Myocardial Function in Newborn Infants.

Propofol Formulation Affects Myocardial Function in Newborn Infants.

Authors :
Massolo AC
Sgrò S
Piersigilli F
Allegaert K
Capolupo I
Rechichi J
Landolfo F
Calzolari F
Toscano A
Picardo S
Patel N
Source :
Pediatric cardiology [Pediatr Cardiol] 2019 Oct; Vol. 40 (7), pp. 1536-1542. Date of Electronic Publication: 2019 Aug 14.
Publication Year :
2019

Abstract

This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who received a diluted formulation (Pd) of equal volumes propofol 1% and 0.9% NaCl. Echocardiograms were performed pre (t <subscript>0</subscript> )-, immediately post (t <subscript>1</subscript> )-, and 1-h post (t <subscript>2</subscript> ) propofol administration. Myocardial deformation was assessed with tissue Doppler imaging (TDI) analysis and peak longitudinal strain (LS). 18 cases were included: nine (50%) P1% and nine (50%) Pd. In the P1% group, TDI velocities and LS were significantly reduced at t <subscript>1</subscript> and t <subscript>2</subscript> . In the Pd Group, only TDI velocities in the left ventricle were reduced at t <subscript>1</subscript> , but not at t <subscript>2</subscript> . Dilution of propofol may minimize myocardial dysfunction while maintaining adequate sedation in infants. Further comparative studies are needed to investigate the safety and efficacy of this approach.

Details

Language :
English
ISSN :
1432-1971
Volume :
40
Issue :
7
Database :
MEDLINE
Journal :
Pediatric cardiology
Publication Type :
Academic Journal
Accession number :
31414158
Full Text :
https://doi.org/10.1007/s00246-019-02182-4