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Night Blindness in Cystic Fibrosis: The Key Role of Vitamin A in the Digestive System.
- Source :
-
Nutrients [Nutrients] 2019 Aug 13; Vol. 11 (8). Date of Electronic Publication: 2019 Aug 13. - Publication Year :
- 2019
-
Abstract
- Vitamin A is a fundamental micronutrient that regulates various cellular patterns. Vitamin A deficiency (VAT) is a worldwide problem and the primary cause of nocturnal blindness especially in low income countries. Cystic fibrosis (CF) is a known risk factor of VAD because of liposoluble vitamin malabsorption due to pancreatic insufficiency. We describe a case of a 9-year-old girl who experienced recurrent episodes of nocturnal blindness due to profound VAD. This little girl is paradigmatic for the explanation of the key role of the gut-liver axis in vitamin A metabolism. She presents with meconium ileus at birth, requiring intestinal resection that led to a transient intestinal failure with parenteral nutrition need. In addition, she suffered from cholestatic liver disease due to CF and intestinal failure-associated liver disease. The interaction of pancreatic function, intestinal absorption and liver storage is fundamental for the correct metabolism of vitamin A.
- Subjects :
- Child
Cystic Fibrosis diagnosis
Dietary Supplements
Female
Humans
Night Blindness diagnosis
Night Blindness physiopathology
Night Blindness therapy
Nutritional Status
Parenteral Nutrition, Home
Recurrence
Short Bowel Syndrome diagnosis
Short Bowel Syndrome physiopathology
Short Bowel Syndrome therapy
Treatment Outcome
Vitamin A administration & dosage
Vitamin A metabolism
Vitamin A Deficiency diagnosis
Vitamin A Deficiency physiopathology
Vitamin A Deficiency therapy
Cystic Fibrosis complications
Intestinal Absorption
Night Blindness etiology
Night Vision
Short Bowel Syndrome complications
Vitamin A Deficiency etiology
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 11
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Report
- Accession number :
- 31412557
- Full Text :
- https://doi.org/10.3390/nu11081876