Intercalary heterochromatin of Drosophila as a potential model for human fragile sites.

Authors :: Laird CD
Lamb MM
Source :: American journal of medical genetics [Am J Med Genet] 1988 May-Jun; Vol. 30 (1-2), pp. 689-91.
Publication Year :: 1988
Abstract: We summarize our proposal that "intercalary heterochromatin" of Drosophila is a useful model for human fragile sites. Comparison with Drosophila site 11A suggests that the normal allele of fragile site Xq27 is a meiotic pairing site.

Subjects :: Animals
Chromosome Fragile Sites
Fragile X Syndrome genetics
Humans
X Chromosome
Chromosome Fragility
Drosophila melanogaster genetics
Heterochromatin ultrastructure
Models, Genetic

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