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Pyruvate kinase M2: A simple molecule with complex functions.

Authors :
Alquraishi M
Puckett DL
Alani DS
Humidat AS
Frankel VD
Donohoe DR
Whelan J
Bettaieb A
Source :
Free radical biology & medicine [Free Radic Biol Med] 2019 Nov 01; Vol. 143, pp. 176-192. Date of Electronic Publication: 2019 Aug 08.
Publication Year :
2019

Abstract

Pyruvate kinase M2 is a critical enzyme that regulates cell metabolism and growth under different physiological conditions. In its metabolic role, pyruvate kinase M2 catalyzes the last glycolytic step which converts phosphoenolpyruvate to pyruvate with the generation of ATP. Beyond this metabolic role in glycolysis, PKM2 regulates gene expression in the nucleus, phosphorylates several essential proteins that regulate major cell signaling pathways, and contribute to the redox homeostasis of cancer cells. The expression of PKM2 has been demonstrated to be significantly elevated in several types of cancer, and the overall inflammatory response. The unusual pattern of PKM2 expression inspired scientists to investigate the unrevealed functions of PKM2 and the therapeutic potential of targeting PKM2 in cancer and other disorders. Therefore, the purpose of this review is to discuss the mechanistic and therapeutic potential of targeting PKM2 with the focus on cancer metabolism, redox homeostasis, inflammation, and metabolic disorders. This review highlights and provides insight into the metabolic and non-metabolic functions of PKM2 and its relevant association with health and disease.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1873-4596
Volume :
143
Database :
MEDLINE
Journal :
Free radical biology & medicine
Publication Type :
Academic Journal
Accession number :
31401304
Full Text :
https://doi.org/10.1016/j.freeradbiomed.2019.08.007