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Divergent clonal evolution of a common precursor to mantle cell lymphoma and classic Hodgkin lymphoma.
- Source :
-
Cold Spring Harbor molecular case studies [Cold Spring Harb Mol Case Stud] 2019 Dec 13; Vol. 5 (6). Date of Electronic Publication: 2019 Dec 13 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Clonal heterogeneity and evolution of mantle cell lymphoma (MCL) remain unclear despite the progress in our understanding of its biology. Here, we report a 71-yr-old male patient with an aggressive MCL and depict the clonal evolution from initial diagnosis of typical MCL to relapsed blastoid MCL. During the course of the disease, the patient was diagnosed with classic Hodgkin lymphoma (CHL) and received a CHL therapeutic regimen. Molecular analysis by next-generation sequencing of both MCL and CHL demonstrated clonally related CHL with characteristic immunophenotype and PDL1/2 gains. Moreover, our data illustrate the clonal heterogeneity and acquisition of additional genetic aberrations including a rare fusion of SEC22B-NOTCH2 in the process of clonal evolution. Evidence obtained from our comprehensive immunophenotypic and genetic studies indicates that MCL and CHL can originate from a common precursor by divergent clonal evolution, which may pose a therapeutic challenge.<br /> (© 2019 Tashkandi et al.; Published by Cold Spring Harbor Laboratory Press.)
- Subjects :
- Aged
B7-H1 Antigen genetics
Cell Proliferation genetics
Clonal Evolution genetics
High-Throughput Nucleotide Sequencing
Hodgkin Disease genetics
Hodgkin Disease pathology
Humans
Lymphoma, Mantle-Cell pathology
Male
R-SNARE Proteins genetics
Receptor, Notch2 genetics
Lymphoma, Mantle-Cell diagnosis
Lymphoma, Mantle-Cell genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2373-2873
- Volume :
- 5
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor molecular case studies
- Publication Type :
- Academic Journal
- Accession number :
- 31395597
- Full Text :
- https://doi.org/10.1101/mcs.a004259