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DDAH1 and DDAH2 polymorphisms associate with asymmetrical dimethylarginine plasma levels in erectile dysfunction patients but not in healthy controls.
- Source :
-
Nitric oxide : biology and chemistry [Nitric Oxide] 2019 Nov 01; Vol. 92, pp. 11-17. Date of Electronic Publication: 2019 Aug 05. - Publication Year :
- 2019
-
Abstract
- Erectile Dysfunction (ED) is one of the main complaints of aging male. A reduced production of Nitric Oxide (NO) may be involved in ED pathogenesis. NO is synthesized from l-Arginine, and asymmetrical dimethylarginine inhibits all NO synthases. DDAH1 and DDAH2 are genes that encode enzymes responsible for metabolizing ADMA. We aimed to assess whether: 1) ADMA and nitrite levels associated with ED risk and with symptoms intensity; and whether 2) DDAH1 and DDAH2 gene polymorphisms associate with changes in biochemical data, and with ED risk and symptoms intensity. In this study were included 98 healthy controls and 130 ED patients. ADMA levels were measured by ELISA and nitrite levels by Chemiluminescence. DDAH1 and DDAH2 polymorphisms were assessed by Taqman assays. We found that ED had increased nitrite levels and lower ADMA levels than Control group (P < 0.05). We found a significant correlation of ADMA with Nitrite levels only in ED (B = -0.57, P < 0.001). Genotypes and haplotypes of DDAH1 were associated with ADMA levels in ED (P < 0.05), while haplotypes of DDAH2 were associated with levels of nitrite in ED (P < 0.05). Erectile dysfunction patients show an association between DDAH1 and DDAH2 polymorphisms with ADMA levels, which in turn are negatively correlated with nitrite levels. This is not evident on healthy controls.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Amidohydrolases antagonists & inhibitors
Amidohydrolases metabolism
Arginine blood
Arginine pharmacology
Female
Humans
Male
Middle Aged
Nitric Oxide biosynthesis
Amidohydrolases genetics
Arginine analogs & derivatives
Erectile Dysfunction blood
Erectile Dysfunction enzymology
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8611
- Volume :
- 92
- Database :
- MEDLINE
- Journal :
- Nitric oxide : biology and chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31394201
- Full Text :
- https://doi.org/10.1016/j.niox.2019.08.001