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Intracerebroventricular microinjection of kaempferol on memory retention of passive avoidance learning in rats: involvement of cholinergic mechanism(s).
- Source :
-
The International journal of neuroscience [Int J Neurosci] 2019 Dec; Vol. 129 (12), pp. 1203-1212. Date of Electronic Publication: 2019 Aug 26. - Publication Year :
- 2019
-
Abstract
- Purpose of the study: Kaempferol (KM) is a flavonoid found in plant-derived foods and medicinal plants. Recently, it is well established that KM plays a protective role to develop Alzheimer's disease. The current study aimed at evaluating the effect of intracerebroventricular micro-injection of KM on memory retention of passive avoidance learning (MRPAM) and identifying the potentially related cholinergic mechanisms (ChMs) in rats. Materials and methods: In the current study, male Wistar rats randomly divided into control, vehicle and KM (10, 20 and 40 μg/rat) groups. Moreover, MRPAM was evaluated by shuttle box test. The role of ChM was studied using non-selective and selective acetylcholine antagonists (scopolamine [SCN], 4-DAMP and methoctramine [MN], respectively) as well as pirenzepine (PZ) in combination with KM. Results: The employment of KM (40 μg/rat) improved the SCN-induced memory impairment in MRPAM. Co-treatment with KM (40 μg/rat) plus 4-DAMP significantly increased the step-through latency (STL, P < 0.05; 167 ± 28 s) and decreased the total dark chamber (TDC, P < 0.05; 121 ± 31 s) compared with those of the 4-DAMP group (STL: 75 ± 13 s; TDC: 178 ± 46 s). Co-treatment with KM (40 μg/rat) plus PZ attenuated STL, and also increased TDC ( P < 0.01; 220 ± 28 s) compared with those of the PZ group. Co-treatment with KM (10 and 20 μg/rat) and MN increased STL ( P < 0.05), and deceased TDC compared with those of the MN group ( P < 0.01). Conclusions: Totally, the results of the present study showed that cholinergic system may be involved in improving effect of KM on SCN-induced memory impairment.
- Subjects :
- Animals
Avoidance Learning physiology
Diamines administration & dosage
Injections, Intraventricular
Male
Memory physiology
Microinjections
Piperidines administration & dosage
Pirenzepine administration & dosage
Rats, Wistar
Scopolamine administration & dosage
Acetylcholine physiology
Avoidance Learning drug effects
Cholinergic Antagonists administration & dosage
Kaempferols administration & dosage
Memory drug effects
Muscarinic Antagonists administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1563-5279
- Volume :
- 129
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The International journal of neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 31393204
- Full Text :
- https://doi.org/10.1080/00207454.2019.1653867