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Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy.

Hydrogen Sulfide: Recent Progression and Perspectives for the Treatment of Diabetic Nephropathy.

Authors :
Sun HJ
Wu ZY
Cao L
Zhu MY
Liu TT
Guo L
Lin Y
Nie XW
Bian JS
Source :
Molecules (Basel, Switzerland) [Molecules] 2019 Aug 06; Vol. 24 (15). Date of Electronic Publication: 2019 Aug 06.
Publication Year :
2019

Abstract

Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide. Hydrogen sulfide (H <subscript>2</subscript> S), the third gasotransmitter after nitric oxide (NO) and carbon monoxide (CO), is synthesized in nearly all organs, including the kidney. Though studies on H <subscript>2</subscript> S regulation of renal physiology and pathophysiology are still in its infancy, emerging evidence shows that H <subscript>2</subscript> S production by renal cells is reduced under disease states and H <subscript>2</subscript> S donors ameliorate kidney injury. Specifically, aberrant H <subscript>2</subscript> S level is implicated in various renal pathological conditions including diabetic nephropathy. This review presents the roles of H <subscript>2</subscript> S in diabetic renal disease and the underlying mechanisms for the protective effects of H <subscript>2</subscript> S against diabetic renal damage. H <subscript>2</subscript> S may serve as fundamental strategies to treat diabetic kidney disease. These H <subscript>2</subscript> S treatment modalities include precursors for H <subscript>2</subscript> S synthesis, H <subscript>2</subscript> S donors, and natural plant-derived compounds. Despite accumulating evidence from experimental studies suggests the potential role of the H <subscript>2</subscript> S signaling pathway in the treatment of diabetic nephropathy, these results need further clinical translation. Expanding understanding of H <subscript>2</subscript> S in the kidney may be vital to translate H <subscript>2</subscript> S to be a novel therapy for diabetic renal disease.<br />Competing Interests: The author declares no conflict of interest.

Details

Language :
English
ISSN :
1420-3049
Volume :
24
Issue :
15
Database :
MEDLINE
Journal :
Molecules (Basel, Switzerland)
Publication Type :
Academic Journal
Accession number :
31390847
Full Text :
https://doi.org/10.3390/molecules24152857