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Having co-morbid cardiovascular disease at time of cancer diagnosis: already one step behind when it comes to HRQoL?
- Source :
-
Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2019 Dec; Vol. 58 (12), pp. 1684-1691. Date of Electronic Publication: 2019 Aug 07. - Publication Year :
- 2019
-
Abstract
- Background: The relation between cardiovascular disease (CVD) present at the time of cancer diagnosis and Health-Related Quality of Life (HRQoL) assessed years after cancer diagnosis has - to our knowledge - not been studied. The objective is, therefore, to examine the relation between co-morbid CVD at cancer diagnosis and HRQoL among cancer survivors diagnosed with colorectal, thyroid, prostate, endometrium, ovarian cancer, melanoma, (non-)Hodgkin lymphoma, chronic lymphocytic leukemia (CLL), or multiple myeloma (MM) in an exploratory population-based cross-sectional study. Material and methods: Analyses were performed on combined data sets from the PROFILES and Netherlands Cancer Registry (NCR). Data on co-morbid CVD at cancer diagnosis was extracted from the NCR. HRQoL was measured via PROFILES at a median of 4.6 years after cancer diagnosis. General Linear Model Analyses were run for the total group of cancer survivors and for each malignancy. Results: In total, 5930 cancer survivors (2281 colorectal, 280 thyroid, 1054 prostate, 177 endometrium, 389 ovarian cancer, 212 melanoma, 874 non-Hodgkin and 194 Hodgkin lymphoma, 242 CLL, and 227 MM survivors) were included. For the total group, survivors who had a CVD at cancer diagnosis ( n = 1441, 23.4%) reported statistically significant and clinically important lower scores on global QoL and physical functioning and higher scores for dyspnea ( p < .05) compared to those without CVD. Co-morbid CVD at cancer diagnosis was negatively related to global QoL, the five functional scales and the symptoms fatigue and dyspnea across most malignancies (i.e., colorectal, and prostate cancer, non-Hodgkin lymphoma, ovarium cancer, melanoma, and CLL). No significant relations were found among thyroid and endometrium cancer, Hodgkin lymphoma and MM survivors, likely due to small numbers. Conclusion: In conclusion, co-morbid CVD at cancer diagnosis was negatively related to HRQoL, especially to global QoL, physical and role functioning, and the symptoms fatigue and dyspnea.
- Subjects :
- Angina Pectoris epidemiology
Arrhythmias, Cardiac epidemiology
Colorectal Neoplasms epidemiology
Comorbidity
Coronary Artery Disease epidemiology
Cross-Sectional Studies
Dyspnea epidemiology
Fatigue epidemiology
Female
Humans
Lymphoma, Non-Hodgkin epidemiology
Male
Middle Aged
Myocardial Infarction epidemiology
Netherlands epidemiology
Peripheral Arterial Disease epidemiology
Prostatic Neoplasms epidemiology
Cancer Survivors statistics & numerical data
Cardiovascular Diseases epidemiology
Neoplasms diagnosis
Neoplasms epidemiology
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1651-226X
- Volume :
- 58
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Acta oncologica (Stockholm, Sweden)
- Publication Type :
- Academic Journal
- Accession number :
- 31389275
- Full Text :
- https://doi.org/10.1080/0284186X.2019.1648861