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Neonatal jaundice in association with autism spectrum disorder and developmental disorder.
- Source :
-
Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2020 Feb; Vol. 40 (2), pp. 219-225. Date of Electronic Publication: 2019 Aug 06. - Publication Year :
- 2020
-
Abstract
- Objective: To examine the association between neonatal jaundice and autism spectrum disorder (ASD) and non-ASD developmental disorder (DD).<br />Study Design: We analyzed data from the Study to Explore Early Development, a US multisite, case-control study conducted from 2007 to 2011. Developmental assessment classified children aged 2-5 years into: ASD (n = 636), DD (n = 777), or controls (POP; n = 926). Neonatal jaundice (n = 1054) was identified from medical records and maternal interviews. We examined associations between neonatal jaundice and ASD and DD using regression models to obtain adjusted odds ratios (aOR).<br />Results: Our results showed interaction between gestational age and neonatal jaundice. Neonatal jaundice was associated with ASD at 35-37 weeks (aOR = 1.83, 95%CI 1.05, 3.19), but not ≥38 weeks gestation (aOR = 0.97, 95%CI 0.76, 1.24). Similar results were observed with DD.<br />Conclusions: Further exploration of timing and severity of neonatal jaundice and ASD/DD is warranted.
Details
- Language :
- English
- ISSN :
- 1476-5543
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of perinatology : official journal of the California Perinatal Association
- Publication Type :
- Academic Journal
- Accession number :
- 31388117
- Full Text :
- https://doi.org/10.1038/s41372-019-0452-4