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European propolis is highly active against trypanosomatids including Crithidia fasciculata.
- Source :
-
Scientific reports [Sci Rep] 2019 Aug 06; Vol. 9 (1), pp. 11364. Date of Electronic Publication: 2019 Aug 06. - Publication Year :
- 2019
-
Abstract
- Extracts of 35 samples of European propolis were tested against wild type and resistant strains of the protozoal pathogens Trypanosoma brucei, Trypanosoma congolense and Leishmania mexicana. The extracts were also tested against Crithidia fasciculata a close relative of Crithidia mellificae, a parasite of bees. Crithidia, Trypanosoma and Leishmania are all members of the order Kinetoplastida. High levels of activity were obtained for all the samples with the levels of activity varying across the sample set. The highest levels of activity were found against L. mexicana. The propolis samples were profiled by using liquid chromatography with high resolution mass spectrometry (LC-MS) and principal components analysis (PCA) of the data obtained indicated there was a wide variation in the composition of the propolis samples. Orthogonal partial least squares (OPLS) associated a butyrate ester of pinobanksin with high activity against T. brucei whereas in the case of T. congolense high activity was associated with methyl ethers of chrysin and pinobanksin. In the case of C. fasciculata highest activity was associated with methyl ethers of galangin and pinobanksin. OPLS modelling of the activities against L. mexicana using the mass spectrometry produced a less successful model suggesting a wider range of active components.
- Subjects :
- Animals
Antiprotozoal Agents therapeutic use
Chromatography, Liquid
Euglenozoa Infections drug therapy
Flavanones analysis
Flavanones pharmacology
Flavonoids analysis
Flavonoids pharmacology
Mass Spectrometry
Propolis chemistry
Propolis therapeutic use
Antiprotozoal Agents pharmacology
Crithidia fasciculata drug effects
Propolis pharmacology
Trypanosoma brucei brucei drug effects
Trypanosoma congolense drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 31388043
- Full Text :
- https://doi.org/10.1038/s41598-019-47840-y