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Gastric cancer: epidemiology, biology, and prevention: a mini review.
- Source :
-
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) [Eur J Cancer Prev] 2019 Sep; Vol. 28 (5), pp. 397-412. - Publication Year :
- 2019
-
Abstract
- Gastric cancer is one of the most common causes of cancer-related mortality worldwide. The objective of this article is to review the epidemiology and biology of gastric cancer risk. This literature review explores the biological, clinical, and environmental factors that influence the rates of this disease and discuss the different intervention methods that may not only increase the awareness of gastric cancer but also increase screening in efforts to reduce the risk of gastric cancer. Helicobacter pylori infection is the primary risk factor for gastric cancer. Additional risk factors include geographical location, age, sex, smoking, socioeconomic status, dietary intake, and genetics. Primary and secondary prevention strategies such as dietary modifications and screenings are important measures for reducing the risk of gastric cancer. Interventions, such as H. pylori eradication through chemoprevention trials, have shown some potential as a preventative strategy. Although knowledge about gastric cancer risk has greatly increased, future research is warranted on the differentiation of gastric cancer epidemiology by subsite and exploring the interactions between H. pylori infection, genetics, and environmental factors. Better understanding of these relationships can help researchers determine the most effective intervention strategies for reducing the risk of this disease.
- Subjects :
- Age Factors
Alcohol Drinking adverse effects
Alcohol Drinking epidemiology
Anti-Bacterial Agents therapeutic use
Chemoprevention methods
Feeding Behavior physiology
Gastric Mucosa microbiology
Genetic Predisposition to Disease
Geography
Helicobacter Infections drug therapy
Helicobacter Infections microbiology
Helicobacter Infections pathology
Humans
Metaplasia epidemiology
Metaplasia microbiology
Metaplasia pathology
Metaplasia prevention & control
Proton Pump Inhibitors therapeutic use
Randomized Controlled Trials as Topic
Risk Factors
Sex Factors
Smoking adverse effects
Social Class
Stomach Neoplasms etiology
Stomach Neoplasms pathology
Stomach Neoplasms prevention & control
Treatment Outcome
Gastric Mucosa pathology
Helicobacter Infections epidemiology
Helicobacter pylori pathogenicity
Smoking epidemiology
Stomach Neoplasms epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5709
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
- Publication Type :
- Academic Journal
- Accession number :
- 31386635
- Full Text :
- https://doi.org/10.1097/CEJ.0000000000000480