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Visible light-activatable multicargo microemulsions with bimodal photobactericidal action and dual colour fluorescence.

Authors :
Fraix A
Catanzano O
Di Bari I
Conte C
Seggio M
Parisi C
Nostro A
Ginestra G
Quaglia F
Sortino S
Source :
Journal of materials chemistry. B [J Mater Chem B] 2019 Sep 14; Vol. 7 (34), pp. 5257-5264. Date of Electronic Publication: 2019 Aug 06.
Publication Year :
2019

Abstract

In this contribution we report the design, preparation, and physico-chemical, photophysical and photochemical characterization of photoactivatable microemulsions (MEs) based on Labrasol®, isopropanol and Lauroglycol® FCC as a surfactant, co-surfactant and oily phase, respectively. The MEs co-incorporate, in their oil phase, two lipophilic guests such as a red emitting singlet oxygen ( <superscript>1</superscript> O <subscript>2</subscript> ) photosensitizer (PS) and a tailored green emitting nitric oxide (NO) photodonor (NOPD). These two chromofluorogenic units absorb in different spectral windows of the visible range, and their individual photophysical and photochemical properties are well-conserved when co-entrapped in the microemulsions. These features permit the PS and NOPD to operate either individually or in tandem resulting in (i) red, green or both fluorescence emission, (ii) photogeneration of cytotoxic <superscript>1</superscript> O <subscript>2</subscript> , NO or both and (iii) amplified photobactericidal action against Staphylococcus aureus due to the combined effect of these two antibacterial agents.

Details

Language :
English
ISSN :
2050-7518
Volume :
7
Issue :
34
Database :
MEDLINE
Journal :
Journal of materials chemistry. B
Publication Type :
Academic Journal
Accession number :
31384869
Full Text :
https://doi.org/10.1039/c9tb00699k