Back to Search
Start Over
Joint profiling of DNA methylation and chromatin architecture in single cells.
- Source :
-
Nature methods [Nat Methods] 2019 Oct; Vol. 16 (10), pp. 991-993. Date of Electronic Publication: 2019 Aug 05. - Publication Year :
- 2019
-
Abstract
- We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
Details
- Language :
- English
- ISSN :
- 1548-7105
- Volume :
- 16
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nature methods
- Publication Type :
- Academic Journal
- Accession number :
- 31384045
- Full Text :
- https://doi.org/10.1038/s41592-019-0502-z