Back to Search
Start Over
Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors.
- Source :
-
Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2019 Jul 18; Vol. 9, pp. 262. Date of Electronic Publication: 2019 Jul 18 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases. Recently, the regulation between host immunologic response and periodontal pathogens has become a hotspot to explain the mechanism of periodontitis and related systemic diseases. Since Porphyromonas gingivalis ( P. gingivalis ) was proved as critical periodontal pathogen above all, researches focusing on the mechanism of its virulence factors have received extensive attention. Studies have shown that in the development of periodontitis, in addition to the direct release of virulent factors by periodontal pathogens to destroy periodontal tissues, over-low or over-high intrinsic immune and inflammatory response mediated by Toll-like receptors (TLRs) can lead to more lasting destruction of periodontal tissues. It is very necessary to sort out how various cytopathic factors of P. gingivalis mediate inflammation and immune responses between the host through TLRs so as to help precisely prevent, diagnose, and treat periodontitis in clinic. This review summarizes the role of three most widely studied pathogenic factors produced by P. gingivalis (lipopolysaccharide, gingipains, pili) and their interactions with TLRs at the cellular and molecular level in the progress of periodontitis.
- Subjects :
- Animals
Bacteroidaceae Infections microbiology
Bacteroidaceae Infections pathology
Bacteroidaceae Infections physiopathology
Disease Models, Animal
Humans
Periodontitis microbiology
Periodontitis pathology
Periodontitis physiopathology
Fimbriae, Bacterial metabolism
Gingipain Cysteine Endopeptidases metabolism
Host-Pathogen Interactions
Lipopolysaccharides metabolism
Porphyromonas gingivalis pathogenicity
Toll-Like Receptors metabolism
Virulence Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2235-2988
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Frontiers in cellular and infection microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 31380305
- Full Text :
- https://doi.org/10.3389/fcimb.2019.00262