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Genetic risk for Alzheimer's disease and functional brain connectivity in children and adolescents.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2019 Oct; Vol. 82, pp. 10-17. Date of Electronic Publication: 2019 Jul 06. - Publication Year :
- 2019
-
Abstract
- Research suggested accumulation of tau proteins might lead to the degeneration of functional networks. Studies investigating the impact of genetic risk for Alzheimer's disease (AD) on early brain connections might shed light on mechanisms leading to AD development later in life. Here, we aim to investigate whether the polygenic risk score for Alzheimer's disease (AD-PRS) influences the connectivity among regions susceptible to tau pathology during childhood and adolescence. Participants were youth, aged 6-14 years, and recruited in Porto Alegre (discovery sample, n = 332) and São Paulo (replication sample, n = 304), Brazil. Subjects underwent genotyping and 6-min resting state funcional magnetic resonance imaging. Connections between the local maxima of tau pathology networks were used as dependent variables. The AD-PRS was associated with the connectivity between the right precuneus and the right superior temporal gyrus (discovery sample: β = 0.180, p <subscript>adjusted</subscript>  = 0.036; replication sample: β = 0.202, p = 0.031). This connectivity was also associated with inhibitory control (β = 0.157, p <subscript>adjusted</subscript>  = 0.035) and moderated the association between the AD-PRS and both immediate and delayed recall. These findings suggest the AD-PRS may affect brain connectivity in youth, which might impact memory performance and inhibitory control in early life.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Alzheimer Disease epidemiology
Brazil epidemiology
Child
Cross-Sectional Studies
Female
Functional Neuroimaging methods
Genetic Predisposition to Disease epidemiology
Humans
Male
Alzheimer Disease diagnostic imaging
Alzheimer Disease genetics
Brain diagnostic imaging
Genetic Predisposition to Disease genetics
Nerve Net diagnostic imaging
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 82
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 31376729
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2019.06.011