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Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

Authors :
Xu P
Ianes C
Gärtner F
Liu C
Burster T
Bakulev V
Rachidi N
Knippschild U
Bischof J
Source :
Gene [Gene] 2019 Oct 05; Vol. 715, pp. 144005. Date of Electronic Publication: 2019 Jul 31.
Publication Year :
2019

Abstract

Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their dysregulation as well as mutations within their coding regions contribute to the development of various different pathologies, including cancer and neurodegenerative diseases, they have become interesting new drug targets within the last decade. However, to develop optimized CK1 isoform-specific therapeutics in personalized therapy concepts, a detailed knowledge of the regulation and functions of the different CK1 isoforms, their various splice variants and orthologs is mandatory. In this review we will focus on the stress-induced CK1 isoform delta (CK1δ), thereby addressing its regulation, physiological functions, the consequences of its deregulation for the development and progression of diseases, and its potential as therapeutic drug target.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0038
Volume :
715
Database :
MEDLINE
Journal :
Gene
Publication Type :
Academic Journal
Accession number :
31376410
Full Text :
https://doi.org/10.1016/j.gene.2019.144005