Back to Search
Start Over
TeraVR empowers precise reconstruction of complete 3-D neuronal morphology in the whole brain.
- Source :
-
Nature communications [Nat Commun] 2019 Aug 02; Vol. 10 (1), pp. 3474. Date of Electronic Publication: 2019 Aug 02. - Publication Year :
- 2019
-
Abstract
- Neuron morphology is recognized as a key determinant of cell type, yet the quantitative profiling of a mammalian neuron's complete three-dimensional (3-D) morphology remains arduous when the neuron has complex arborization and long projection. Whole-brain reconstruction of neuron morphology is even more challenging as it involves processing tens of teravoxels of imaging data. Validating such reconstructions is extremely laborious. We develop TeraVR, an open-source virtual reality annotation system, to address these challenges. TeraVR integrates immersive and collaborative 3-D visualization, interaction, and hierarchical streaming of teravoxel-scale images. Using TeraVR, we have produced precise 3-D full morphology of long-projecting neurons in whole mouse brains and developed a collaborative workflow for highly accurate neuronal reconstruction.
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 31375678
- Full Text :
- https://doi.org/10.1038/s41467-019-11443-y