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Comparative in vitro activity of the new oral cephalosporin cefixime.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 1988 Jun; Vol. 7 (3), pp. 428-31. - Publication Year :
- 1988
-
Abstract
- Cefixime was 8 to 10 times more active than cefaclor and augmentin against isolates of Escherichia coli, Klebsiella pneumoniae and Salmonella typhi, MIC90 values ranging from 0.06 to 0.25 micrograms/ml. However, none of these three drugs was particularly active against isolates of more resistant gram-negative bacilli such as Enterobacter, Serratia, Citrobacter, Acinetobacter, Providencia and Achromobacter spp. The lowest MIC values for gram-negative bacilli were seen with ciprofloxacin, except for isolates of Acinetobacter, where cotrimoxazole was the most active of the five drugs studied. Augmentin and ciprofloxacin exhibited the lowest MICs for isolates of streptococci and corynebacteria. Although cefixime may be among the most active oral beta-lactam drugs, it does not appear to be useful for treatment of infections caused by more resistant gram-negative bacilli.
- Subjects :
- Amoxicillin blood
Amoxicillin pharmacology
Amoxicillin-Potassium Clavulanate Combination
Cefaclor blood
Cefaclor pharmacology
Cefixime
Cefotaxime administration & dosage
Cefotaxime blood
Cefotaxime pharmacology
Clavulanic Acids blood
Clavulanic Acids pharmacology
Drug Resistance, Microbial
Escherichia coli drug effects
Humans
Klebsiella pneumoniae drug effects
Salmonella typhi drug effects
Cefotaxime analogs & derivatives
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0934-9723
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 3137053
- Full Text :
- https://doi.org/10.1007/BF01962357