Back to Search
Start Over
Evaluation of hepatic and kidney dysfunction among newly diagnosed HIV patients with viral hepatitis infection in Cape Coast, Ghana.
- Source :
-
BMC research notes [BMC Res Notes] 2019 Jul 31; Vol. 12 (1), pp. 466. Date of Electronic Publication: 2019 Jul 31. - Publication Year :
- 2019
-
Abstract
- Objective: HIV positive individuals infected with viral hepatitis B (HBV) or C (HCV) are at an increased risk of progression to kidney and liver failures. Therefore, prior to initiation of antiretroviral therapy, early diagnosis and initiation of appropriate treatment protocols are imperative for co-infected individuals. This study evaluated the prevalence of HBV and HCV, and extent of liver and renal dysfunction among 90 newly diagnosed HIV patients attending the Cape Coast Teaching Hospital HIV clinic.<br />Results: Levels of alanine aminotransferase, aspartate-platelet ratio index and estimated glomerular filtration rate were used respectively to diagnose hepatotoxicity, liver fibrosis and chronic kidney disease (CKD). Association analyses were evaluated by Pearson's Chi-square test or Fisher's exact test and considered significant at p < 0.05. Using rapid diagnostic tests, 75.6% (n = 68) had HIV1 mono-infection, 24.4% (n = 22) had HIV1/HBV co-infection while 0.0% (n = 0) had HIV1/HCV co-infection. The prevalence of hepatotoxicity, liver fibrosis, and CKD were 7.8% (n = 7), 2.2% (n = 2), and 15.5% (n = 14) respectively. Similar proportions of HIV1/HBV and HIV1 were diagnosed with liver fibrosis (p = 0.431). In relation to hepatotoxicity Grade, a high proportion of HIV1/HBV were diagnosed with Grade 2 (p = 0.042). Also, severely reduced kidney function (CKD stage 4) was observed in only HIV1/HBV (n = 2, 9.1%, p = 0.053).
- Subjects :
- Adult
Alanine Transaminase blood
Aspartic Acid blood
Blood Platelets pathology
Coinfection
Cross-Sectional Studies
Female
Ghana epidemiology
Glomerular Filtration Rate
HIV Infections diagnosis
HIV Infections epidemiology
HIV Infections virology
Hepatitis B diagnosis
Hepatitis B epidemiology
Hepatitis B virology
Hepatitis C diagnosis
Hepatitis C epidemiology
Hepatitis C virology
Humans
Kidney metabolism
Kidney virology
Liver metabolism
Liver virology
Liver Cirrhosis diagnosis
Liver Cirrhosis epidemiology
Liver Cirrhosis virology
Liver Function Tests
Male
Middle Aged
Prevalence
Renal Insufficiency, Chronic diagnosis
Renal Insufficiency, Chronic epidemiology
Renal Insufficiency, Chronic virology
HIV Infections physiopathology
Hepatitis B physiopathology
Hepatitis C physiopathology
Kidney physiopathology
Liver physiopathology
Liver Cirrhosis physiopathology
Renal Insufficiency, Chronic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1756-0500
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC research notes
- Publication Type :
- Academic Journal
- Accession number :
- 31366401
- Full Text :
- https://doi.org/10.1186/s13104-019-4513-8