Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase.

Authors :: Liu WE
Chen Z
Yang LP
Au-Yeung HY
Jiang W
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2019 Aug 13; Vol. 55 (66), pp. 9797-9800.
Publication Year :: 2019
Abstract: Molecular tubes with hydrogen bonding donors in their deep hydrophobic cavities are able to selectively bind organophosphorus compounds in water through hydrogen bonding and the hydrophobic effect. They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase.

Subjects :: Calorimetry
Fluorescent Dyes chemistry
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Magnetic Resonance Spectroscopy methods
Thermodynamics
Water chemistry
Acetylcholinesterase drug effects
Cholinesterase Inhibitors chemistry
Cholinesterase Inhibitors toxicity
Nerve Agents chemistry
Nerve Agents toxicity
Paraoxon chemistry
Paraoxon toxicity

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