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[Chemical constituents from green walnut husks and their antitumor activity in vitro].
- Source :
-
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2019 Jun; Vol. 44 (11), pp. 2278-2282. - Publication Year :
- 2019
-
Abstract
- Fourteen chemical constituents, including 5-hydroxy-4-methoxy-1-tetralone(1), 4,8-dihydroxy-1-tetralone(2), 4,5-dihydroxy-α-tetralone(3), blumenol B(4), dehydrovomifoliol(5), megastigm-5-ene-3,9-diol(6), juglanin B(7), blumenol C(8), loliolide(9), oleracone B(10), syringarsinol(11), pinoresinol(12), methyl 4-hydroxy-3-methoxybenzoate(13), and isovanillic acid(14), were isolated from the dichloromethane fraction of 95% methanol extract of green walnut husks by silica gel and MCI column chromatography, and Pre-HPLC. Their structures were determined by spectroscopic methods, such as NMR, MS and so on. Among them, compounds 1, 4-6, 8-13 were isolated from the green walnut husks for the first time, and compounds 4-6, 8, 10, 12, 13 were isolated from the Juglans genus for the first time. All of isolates were detected their inhibitory activities against HeLa, HGC-27 and Ht-29 cell lines by the MTT assay. The result showed that compounds 2, 3, 7, 9 and 11 exhibited inhibitory activity against the tested cell line. The IC_(50) of 7 were 26.5, 9.0, 25.4 μmol·L~(-1), respectively.
- Subjects :
- Antineoplastic Agents, Phytogenic isolation & purification
Chromatography, High Pressure Liquid
HT29 Cells
HeLa Cells
Humans
Molecular Structure
Phytochemicals isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Juglans chemistry
Phytochemicals pharmacology
Plant Extracts chemistry
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-5302
- Volume :
- 44
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Publication Type :
- Academic Journal
- Accession number :
- 31359654
- Full Text :
- https://doi.org/10.19540/j.cnki.cjcmm.20190321.201