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Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2019 Jul 28; Vol. 20 (15). Date of Electronic Publication: 2019 Jul 28. - Publication Year :
- 2019
-
Abstract
- The proper functioning of the monocyte-macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte-macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte-macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.
- Subjects :
- Female
Humans
Inflammation immunology
Inflammation pathology
Macrophages immunology
Menstrual Cycle genetics
Menstrual Cycle immunology
Monocytes immunology
Placenta immunology
Pre-Eclampsia immunology
Pre-Eclampsia pathology
Pregnancy
Pregnancy Complications genetics
Pregnancy Complications immunology
Pregnancy Complications pathology
Immunity, Innate genetics
Inflammation genetics
Mononuclear Phagocyte System immunology
Pre-Eclampsia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 20
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 31357698
- Full Text :
- https://doi.org/10.3390/ijms20153695