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Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice.
- Source :
-
ImmunoHorizons [Immunohorizons] 2019 Jun 11; Vol. 3 (6), pp. 203-207. Date of Electronic Publication: 2019 Jun 11. - Publication Year :
- 2019
-
Abstract
- Mucosal-associated invariant T (MAIT) cells and invariant NK T (iNKT) cells account for the major lymphocyte populations that express invariant TCRα-chains. MAIT cells mostly express the TCRVα19-Jα33 TCR in mice and the TCRVα7.2-Jα33 TCR in humans, whereas iNKT cells express the TCRVα14-Jα18 TCR in mice and the TCRVα24-Jα18 TCR in humans. Both MAIT and iNKT cells have the capacity to quickly produce a variety of cytokines in response to agonist stimuli and to regulate both innate and adaptive immunity. The germline TCRJα18 knockout ( Traj18 <superscript>-/-</superscript> ) mice have been used extensively for studying iNKT cells. Although it has been reported that the TCRα repertoire was narrowed and the level of Trav19-ja33 transcript was decreased in this strain of mice, direct assessment of MAIT cells in these mice has not been reported. We demonstrate in this study that this strain of mice is also defective of MAIT T cells, cautioning data interpretation when using this strain of mice.<br /> (Copyright © 2019 The Authors.)
- Subjects :
- Adoptive Transfer
Animals
Cells, Cultured
Cytokines metabolism
Germ-Line Mutation
Humans
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Antigen, T-Cell genetics
Receptors, Antigen, T-Cell, alpha-beta genetics
Genes, T-Cell Receptor alpha
Mucosal-Associated Invariant T Cells immunology
Mucous Membrane immunology
Natural Killer T-Cells immunology
Receptors, Antigen, T-Cell, alpha-beta physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2573-7732
- Volume :
- 3
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- ImmunoHorizons
- Publication Type :
- Academic Journal
- Accession number :
- 31356166
- Full Text :
- https://doi.org/10.4049/immunohorizons.1900035