Cascade Alkynylation and Highly Selective Hydrogenation Catalyzed by Binaphthyl-Palladium Nanoparticles Accessing Phosphinyl ( Z )-[3]Dendralenes.

A cascade alkynylation and selective hydrogenation catalyzed by covalent binaphthyl-stabilized palladium nanoparticles has been established, providing a novel and highly efficient methodology for accessing Z and Z,Z -selective phosphinyl [3]dendralenes with broad functional group tolerance and good yields. This strategy achieves the first cascade reactions of alkynylation and hydrogenation with chemoselectivity modulated by catalyst loading.