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Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2019 Jul 25; Vol. 24 (15). Date of Electronic Publication: 2019 Jul 25. - Publication Year :
- 2019
-
Abstract
- Aliskiren, a renin inhibitor, has been shown to have cardioprotective and blood pressure (BP) lowering effects. We aimed to determine the effects of nanoparticle-loaded aliskiren on BP, nitric oxide synthase activity (NOS) and structural alterations of the heart and aorta developed due to spontaneous hypertension in rats. Twelve week-old male spontaneously hypertensive rats (SHR) were divided into the untreated group, group treated with powdered or nanoparticle-loaded aliskiren (25 mg/kg/day) and group treated with nanoparticles only for 3 weeks by gavage. BP was measured by tail-cuff plethysmography. NOS activity, eNOS and nNOS protein expressions, and collagen content were determined in both the heart and aorta. Vasoactivity of the mesenteric artery and wall thickness, inner diameter, and cross-sectional area (CSA) of the aorta were analyzed. After 3 weeks, BP was lower in both powdered and nanoparticle-loaded aliskiren groups with a more pronounced effect in the latter case. Only nanoparticle-loaded aliskiren increased the expression of nNOS along with increased NOS activity in the heart (by 30%). Moreover, nanoparticle-loaded aliskiren decreased vasoconstriction of the mesenteric artery and collagen content (by 11%), and CSA (by 25%) in the aorta compared to the powdered aliskiren group. In conclusion, nanoparticle-loaded aliskiren represents a promising drug with antihypertensive and cardioprotective effects.
- Subjects :
- Animals
Biomarkers
Blood Pressure drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Heart drug effects
Hypertension diagnosis
Hypertension drug therapy
Hypertension etiology
Nitric Oxide metabolism
Polyesters chemistry
Rats
Rats, Inbred SHR
Amides administration & dosage
Antihypertensive Agents administration & dosage
Cardiovascular System drug effects
Drug Carriers chemistry
Fumarates administration & dosage
Nanoparticles chemistry
Nanoparticles ultrastructure
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 24
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 31349653
- Full Text :
- https://doi.org/10.3390/molecules24152710