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Novel Screening Tests for Barrett's Esophagus.
- Source :
-
Current gastroenterology reports [Curr Gastroenterol Rep] 2019 Jul 25; Vol. 21 (9), pp. 42. Date of Electronic Publication: 2019 Jul 25. - Publication Year :
- 2019
-
Abstract
- Purpose of Review: There has been an exponential increase in the incidence of esophageal adenocarcinoma (EAC) over the last half century. Barrett's esophagus (BE) is the only known precursor lesion of EAC. Screening for BE in high-risk populations has been advocated with the aim of identifying BE, followed by endoscopic surveillance to detect dysplasia and early stage cancer, with the intent that treatment can improve outcomes. We aimed to review BE screening methodologies currently recommended and in development.<br />Recent Findings: Unsedated transnasal endoscopy allows for visualization of the distal esophagus, with potential for biopsy acquisition, and can be done in the office setting. Non-endoscopic screening methods being developed couple the use of swallowable esophageal cell sampling devices with BE specific biomarkers, as well as trefoil factor 3, methylated DNA markers, and microRNAs. This approach has promising accuracy. Circulating and exhaled volatile organic compounds and the foregut microbiome are also being explored as means of detecting EAC and BE in a non-invasive manner. Non-invasive diagnostic techniques have shown promise in the detection of BE and may be effective methods of screening high-risk patients.
- Subjects :
- Adenocarcinoma chemistry
Adenocarcinoma etiology
Adenocarcinoma microbiology
Barrett Esophagus complications
Barrett Esophagus genetics
Barrett Esophagus microbiology
Biomarkers, Tumor analysis
Capsule Endoscopy
Esophageal Neoplasms chemistry
Esophageal Neoplasms etiology
Esophageal Neoplasms microbiology
Esophagoscopy
Esophagus chemistry
Esophagus microbiology
Humans
Precancerous Conditions complications
Precancerous Conditions genetics
Precancerous Conditions microbiology
Adenocarcinoma diagnosis
Barrett Esophagus diagnosis
Early Detection of Cancer methods
Esophageal Neoplasms diagnosis
Esophagus pathology
Precancerous Conditions diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1534-312X
- Volume :
- 21
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Current gastroenterology reports
- Publication Type :
- Academic Journal
- Accession number :
- 31346777
- Full Text :
- https://doi.org/10.1007/s11894-019-0710-9