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Prevalence and cumulative incidence of cancer, and mortality in patients with Takotsubo syndrome with focus on the index event.
- Source :
-
QJM : monthly journal of the Association of Physicians [QJM] 2019 Nov 01; Vol. 112 (11), pp. 861-867. - Publication Year :
- 2019
-
Abstract
- Background: It has been suggested that Takotsubo syndrome (TS) is associated with cancer but previous studies have limitations.<br />Aim: To make a comprehensive analysis of prevalence and cumulative incidence of cancer, and mortality among TS patients with focus on the index event.<br />Design: A register-based case-control study.<br />Methods: The first new cancer occurrences (International Classification of Diseases C00-C75, C81-C96) were compared between 505 patients with TS without obstructive coronary artery disease (CAD) and four age- and gender-matched controls comprising patients with acute coronary syndrome with obstructive CAD (CAD controls), respectively, with chest-pain without obstructive CAD at coronary angiography (controls without CAD).<br />Results: The prevalence of cancer before the index event was non-significantly (P = 0.052) higher in TS patients (15.8%) than in CAD controls (11.5%), respectively, higher (P = 0.028) than in controls without CAD (11.1%). There were no differences between the groups in cumulative incidence of cancer after the index event but a higher mortality in TS patients who developed cancer when compared with controls without CAD that developed cancer after the index event (P = 0.018).<br />Conclusions: There is an increased prevalence of first diagnosed cancer in TS patients before the index event but no increased cumulative incidence of cancer after the index event. The results does not support investigation for the possibility of a malignancy specifically in TS patients but in the event of cancer this patient group might need special care. However, if there is lack of a clear stressor it could be of importance to investigate the possibility of a malignancy.<br /> (© The Author(s) 2019. Published by Oxford University Press on behalf of the Association of Physicians.)
- Subjects :
- Aged
Case-Control Studies
Coronary Angiography
Female
Humans
Incidence
Male
Middle Aged
Prevalence
Prognosis
Registries
Risk Assessment methods
Risk Factors
Severity of Illness Index
Survival Analysis
Sweden epidemiology
Coronary Artery Disease complications
Neoplasms epidemiology
Neoplasms mortality
Takotsubo Cardiomyopathy complications
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2393
- Volume :
- 112
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- QJM : monthly journal of the Association of Physicians
- Publication Type :
- Academic Journal
- Accession number :
- 31346617
- Full Text :
- https://doi.org/10.1093/qjmed/hcz186