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Characterization of the First Conotoxin from Conus ateralbus , a Vermivorous Cone Snail from the Cabo Verde Archipelago.
- Source :
-
Marine drugs [Mar Drugs] 2019 Jul 24; Vol. 17 (8). Date of Electronic Publication: 2019 Jul 24. - Publication Year :
- 2019
-
Abstract
- Conus ateralbus is a cone snail endemic to the west side of the island of Sal, in the Cabo Verde Archipelago off West Africa. We describe the isolation and characterization of the first bioactive peptide from the venom of this species. This 30AA venom peptide is named conotoxin AtVIA (δ-conotoxin-like). An excitatory activity was manifested by the peptide on a majority of mouse lumbar dorsal root ganglion neurons. An analog of AtVIA with conservative changes on three amino acid residues at the C-terminal region was synthesized and this analog produced an identical effect on the mouse neurons. AtVIA has homology with δ-conotoxins from other worm-hunters, which include conserved sequence elements that are shared with δ-conotoxins from fish-hunting Conus . In contrast, there is no comparable sequence similarity with δ-conotoxins from the venoms of molluscivorous Conus species. A rationale for the potential presence of δ-conotoxins, that are potent in vertebrate systems in two different lineages of worm-hunting cone snails, is discussed.
- Subjects :
- Amino Acids genetics
Animals
Cabo Verde
Conotoxins pharmacokinetics
Conserved Sequence genetics
Female
Ganglia, Spinal drug effects
Male
Mice
Mice, Inbred C57BL
Neurons drug effects
Peptides chemistry
Peptides genetics
Peptides pharmacokinetics
Phylogeny
Conotoxins chemistry
Conus Snail chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 31344776
- Full Text :
- https://doi.org/10.3390/md17080432