Back to Search
Start Over
A Review of Angiogenic Imbalance in HIV-Infected Hypertensive Disorders of Pregnancy.
- Source :
-
Current hypertension reports [Curr Hypertens Rep] 2019 Jul 24; Vol. 21 (9), pp. 69. Date of Electronic Publication: 2019 Jul 24. - Publication Year :
- 2019
-
Abstract
- Purpose of Review: This review provides a comprehensive insight into the angiogenic profile of hypertensive and normotensive pregnancies compromised by HIV infection. Furthermore, we evaluate the economic implementation of the sFlt-1/PlGF ratio and review the reports on therapeutic apheresis in limiting sFlt-1 production.<br />Recent Findings: In preeclampsia, an increased expression of sFlt-1 triggers angiogenic imbalance. Women of African ancestry have high levels of angiogenic factors than other racial groups. The sFlt-1/PlGF ratio shows promise in the early assessment of preeclampsia, while sFlt-1 apheresis restores angiogenic imbalance. Studies suggest antiretroviral therapy does not impact the angiogenic shift in preeclampsia development. The angiogenic profile in pregnant women of different races influences preeclampsia development. Despite the opposing immune response in HIV infection and preeclampsia, the HIV tat protein strongly mimics vascular endothelial growth factor (VEGF); hence, it is plausible to assume that HIV infection may ameliorate the angiogenic imbalance in preeclampsia.
- Subjects :
- Angiogenic Proteins blood
Angiogenic Proteins physiology
Biomarkers blood
Biomarkers metabolism
Blood Component Removal
Female
HIV Infections blood
HIV Infections complications
Humans
Hypertension, Pregnancy-Induced blood
Hypertension, Pregnancy-Induced physiopathology
Hypertension, Pregnancy-Induced therapy
Membrane Proteins blood
Membrane Proteins physiology
Neovascularization, Pathologic blood
Neovascularization, Pathologic physiopathology
Neovascularization, Physiologic physiology
Pre-Eclampsia blood
Pre-Eclampsia therapy
Pregnancy
Pregnancy Complications, Infectious blood
Vascular Endothelial Growth Factor A blood
Vascular Endothelial Growth Factor A physiology
Vascular Endothelial Growth Factor Receptor-1 blood
Vascular Endothelial Growth Factor Receptor-1 physiology
tat Gene Products, Human Immunodeficiency Virus blood
tat Gene Products, Human Immunodeficiency Virus physiology
HIV Infections physiopathology
Pre-Eclampsia physiopathology
Pregnancy Complications, Infectious physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1534-3111
- Volume :
- 21
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Current hypertension reports
- Publication Type :
- Academic Journal
- Accession number :
- 31342170
- Full Text :
- https://doi.org/10.1007/s11906-019-0970-7