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The cresty neck score is an independent predictor of insulin dysregulation in ponies.
- Source :
-
PloS one [PLoS One] 2019 Jul 24; Vol. 14 (7), pp. e0220203. Date of Electronic Publication: 2019 Jul 24 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Generalized obesity, regional adiposity, hyperinsulinemia and hypertriglyceridemia are all potential indicators of equine metabolic syndrome (EMS). This study aimed to assess the relationship between morphometric measurements of body condition and metabolic hormone concentrations in ponies, with and without a neck crest or generalised obesity. Twenty-six ponies were assigned a body condition score (BCS) and cresty neck score (CNS). Height, girth, and neck measurements were taken. An oral glucose test (OGT; 0.75g dextrose/kg BW) was performed and blood samples collected prior to and 2 hours post dosing. Basal blood samples were analysed for blood glucose, serum insulin, triglyceride and leptin, and plasma HMW adiponectin concentrations. Post-prandial samples were analysed for serum insulin concentration. The ponies were grouped as having a) a normal to fleshy body status (BCS ≤7 and CNS ≤2; n = 10); b) having a high CNS, but without generalised obesity (BCS ≤7 and CNS ≥3; n = 11), or c) being obese (BCS ≥8 and CNS ≥1; n = 5). Responses to the OGT indicated that both normal and insulin-dysregulated ponies were included in the cohort. Post-prandial serum insulin was positively associated with CNS (P<0.035) and ponies with a CNS ≥ 3 had 5 times greater odds of being insulin-dysregulated. The high CNS group had a greater insulin response to the OGT than those in the normal/fleshy group (P = 0.006), whereas obese ponies did not differ from the other two groups. Basal HMW adiponectin was negatively correlated with post-prandial insulin concentrations (r = -0.5, P = 0.009), as well as being decreased in the group with a high CNS, compared to the obese group (P = 0.05). Cresty neck score was more predictive of insulin dysregulation than BCS, and this may be relevant to the diagnosis of EMS. Adiponectin may also be a measure of insulin dysregulation that is independent of body condition.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Anatomy, Veterinary methods
Animals
Biomarkers analysis
Body Weights and Measures methods
Female
Horse Diseases metabolism
Horse Diseases pathology
Horses anatomy & histology
Insulin metabolism
Male
Metabolic Syndrome metabolism
Metabolic Syndrome pathology
Metabolic Syndrome veterinary
Neck pathology
Prognosis
Research Design
Body Weights and Measures veterinary
Horse Diseases diagnosis
Insulin Resistance
Metabolic Syndrome diagnosis
Neck anatomy & histology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 14
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 31339945
- Full Text :
- https://doi.org/10.1371/journal.pone.0220203