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Effect of probiotic and prebiotic versus placebo on appetite in patients with major depressive disorder: post hoc analysis of a randomised clinical trial.
- Source :
-
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association [J Hum Nutr Diet] 2020 Feb; Vol. 33 (1), pp. 56-65. Date of Electronic Publication: 2019 Jul 23. - Publication Year :
- 2020
-
Abstract
- Background: Poor appetite and weight loss are common in melancholic depression. Probiotics and prebiotics have the capacity to affect host behaviour, appetite and weight change by modulating the gut microbiome. The aim of this post hoc analysis was to investigate the effect of supplementation with probiotic and prebiotic on appetite, in parallel with body mass index (BMI), weight and energy intake, in patients with major depressive disorder (MDD).<br />Methods: We extracted data from a clinical trial with 81 patients. The participants were randomly assigned to receive probiotic (Lactobacillus helveticus and Bifidobacterium longum), prebiotic (galactooligosaccharide) or placebo for 8 weeks. Appetite, weight, BMI, dietary intake, serum leptin and physical activity were measured. Subjective appetite rating was evaluated every 2 weeks using visual analogue scales (VAS) to assess satiety, hunger, fullness and desire to eat. Serum leptin was measured by an enzyme-linked immunosorbent assay. Physical activity was measured using the international physical activity questionnaire. A repeated measures analysis of variance model was used to analyse VAS data and analysis of variance/analysis of covariance models for dietary intake, BMI, weight and leptin data.<br />Results: VAS data analyses indicated no significant intervention-time interactions but did show a significant increase over time for desire to eat within the probiotic group (P = 0.025). No significant difference in either BMI or weight was seen among the groups. Energy intake and leptin were significantly increased in the probiotic group compared to the prebiotic.<br />Conclusions: Overall, probiotic supplementation for 8 weeks among MDD patients resulted in improvement of appetite, whereas prebiotic administration had no significant effect on appetite.<br /> (© 2019 The British Dietetic Association Ltd.)
- Subjects :
- Accelerometry
Adult
Analysis of Variance
Bifidobacterium longum
Body Mass Index
Body Weight drug effects
Depressive Disorder, Major microbiology
Double-Blind Method
Energy Intake drug effects
Exercise
Female
Galactose administration & dosage
Humans
Lactobacillus helveticus
Leptin blood
Male
Oligosaccharides administration & dosage
Treatment Outcome
Visual Analog Scale
Appetite drug effects
Depressive Disorder, Major physiopathology
Prebiotics administration & dosage
Probiotics administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1365-277X
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
- Publication Type :
- Academic Journal
- Accession number :
- 31338923
- Full Text :
- https://doi.org/10.1111/jhn.12675