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First European Case of Simultaneous Liver and Pancreas Transplantation as Treatment of Wolcott-Rallison Syndrome in a Small Child.
- Source :
-
Transplantation [Transplantation] 2020 Mar; Vol. 104 (3), pp. 522-525. - Publication Year :
- 2020
-
Abstract
- Background: The concept of organ transplantation as treatment for complex genetic conditions, including Wolcott-Rallison syndrome (WRS), continues to show promise. Liver transplantation is essential for survival of patients with WRS, and pancreas transplantation cures their type I diabetes mellitus.<br />Methods: The recipient, a 3-year-old girl weighing 14 kg at the time of transplantation, suffered from major complications of WRS, including repetitive liver failure episodes and poorly controlled diabetes. The patient underwent a nonacute, combined, simultaneous liver and pancreas transplantation from a pediatric donor without using the en bloc technique.<br />Results: Well-preserved graft functions at 2-year follow-up with normal liver and pancreas function.<br />Conclusions: This is the first case report of simultaneous liver and pancreas transplantation as treatment of WRS in a small child in Europe. Two-year follow-up demonstrates that organ transplantation can halt life-threating recurrent liver failure episodes and cure type 1 diabetes.
- Subjects :
- Child, Preschool
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 diagnosis
Diabetes Mellitus, Type 1 genetics
Epiphyses surgery
Europe
Female
Genetic Testing
Humans
Liver Failure, Acute etiology
Osteochondrodysplasias complications
Osteochondrodysplasias diagnosis
Osteochondrodysplasias genetics
Treatment Outcome
eIF-2 Kinase genetics
Diabetes Mellitus, Type 1 surgery
Epiphyses abnormalities
Liver Failure, Acute surgery
Liver Transplantation methods
Osteochondrodysplasias surgery
Pancreas Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1534-6080
- Volume :
- 104
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 31335762
- Full Text :
- https://doi.org/10.1097/TP.0000000000002869