Back to Search
Start Over
Hepatocellular carcinoma: Mechanisms of progression and immunotherapy.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2019 Jul 07; Vol. 25 (25), pp. 3151-3167. - Publication Year :
- 2019
-
Abstract
- Liver cancer is one of the most common malignancies, and various pathogenic factors can lead to its occurrence and development. Among all primary liver cancers, hepatocellular carcinoma (HCC) is the most common. With extensive studies, an increasing number of molecular mechanisms that promote HCC are being discovered. Surgical resection is still the most effective treatment for patients with early HCC. However, early detection and treatment are difficult for most HCC patients, and the postoperative recurrence rate is high, resulting in poor clinical prognosis of HCC. Although immunotherapy takes longer than conventional chemotherapy to produce therapeutic effects, it persists for longer. In recent years, the emergence of many new immunotherapies, such as immune checkpoint blockade and chimeric antigen receptor T cell therapies, has given new hope for the treatment of HCC.<br />Competing Interests: Conflict-of-interest statement: No potential conflict of interest.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Carcinoma, Hepatocellular immunology
Carcinoma, Hepatocellular pathology
Clinical Trials as Topic
Disease Progression
Humans
Liver Neoplasms immunology
Liver Neoplasms pathology
Neoplasm Recurrence, Local immunology
Neoplasm Recurrence, Local pathology
Neoplasm Recurrence, Local prevention & control
Receptors, Chimeric Antigen immunology
Treatment Outcome
Antineoplastic Agents, Immunological therapeutic use
Cancer Vaccines therapeutic use
Carcinoma, Hepatocellular therapy
Immunotherapy, Adoptive methods
Liver Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 25
- Issue :
- 25
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 31333308
- Full Text :
- https://doi.org/10.3748/wjg.v25.i25.3151