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Methyl helicterilate ameliorates alcohol-induced hepatic fibrosis by modulating TGF-β1/Smads pathway and mitochondria-dependent pathway.
- Source :
-
International immunopharmacology [Int Immunopharmacol] 2019 Oct; Vol. 75, pp. 105759. Date of Electronic Publication: 2019 Jul 17. - Publication Year :
- 2019
-
Abstract
- This study aimed to investigate the effect and underlying mechanism of Methyl helicterilate from Helicteres angustifolia (MHHA) on alcohol-induced hepatic fibrosis. The results showed that MHHA treatment markedly alleviated alcohol-induced liver injury and notably reduced collagen deposition in liver tissue. It significantly enhanced the activity of alcohol dehydrogenase and aldehyde dehydrogenase. Moreover, MHHA treatment markedly decreased the content of inflammatory cytokines, alleviated collagen accumulation, and inhibited the expression of TGF-β1 and Smad2/3 in liver tissue. The experiments in cells showed that MHHA significantly inhibited HSC activation by blocking TGF-β1/Smads signaling pathway. Additionally, it notably induced HSC apoptosis by modulating the mitochondria-dependent pathway. The present study demonstrates that MHHA treatment significantly ameliorates alcoholic hepatic fibrosis and the underlying mechanism may be ascribed to the inhibition of the TGF-β1/Smads pathway and regulation of the mitochondria-mediated apoptotic pathway.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Apoptosis drug effects
Cell Line
Collagen metabolism
Hepatic Stellate Cells drug effects
Humans
Lipid Peroxidation drug effects
Liver drug effects
Liver immunology
Liver pathology
Liver Cirrhosis, Alcoholic immunology
Liver Cirrhosis, Alcoholic metabolism
Liver Cirrhosis, Alcoholic pathology
Male
Rats, Wistar
Signal Transduction drug effects
Triterpenes pharmacology
Liver Cirrhosis, Alcoholic drug therapy
Smad2 Protein immunology
Smad3 Protein immunology
Transforming Growth Factor beta1 immunology
Triterpenes therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1705
- Volume :
- 75
- Database :
- MEDLINE
- Journal :
- International immunopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 31325729
- Full Text :
- https://doi.org/10.1016/j.intimp.2019.105759