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Baseline T1 hyperintense and diffusion-restricted lesions are not linked to prolonged survival in bevacizumab-treated glioblastoma patients of the GLARIUS trial.
- Source :
-
Journal of neuro-oncology [J Neurooncol] 2019 Sep; Vol. 144 (3), pp. 501-509. Date of Electronic Publication: 2019 Jul 19. - Publication Year :
- 2019
-
Abstract
- Purpose: The phase II GLARIUS trial assigned patients with newly diagnosed, O-6-methylguanine-DNA methyltransferase promoter non-methylated glioblastoma to experimental bevacizumab/irinotecan (BEV/IRI) or standard temozolomide (TMZ). To identify subpopulations with a particularly favorable course, we assessed the prognostic potential of magnetic resonance imaging (MRI) markers before treatment onset.<br />Methods: MRIs at baseline (before treatment onset) were analyzed for T1-hyperintense and diffusion-restricted lesions; as well as the presence of both hyperintense and diffusion-restricted (double positive) lesions. The MRI findings were correlated with overall and progression-free survival.<br />Results: MRI scans were evaluable in 71% of the GLARIUS modified intention-to-treat population (n = 121 of 170; 88 patients in the BEV/IRI arm, and 33 patients in the TMZ control arm). Diffusion-restricted and T1 hyperintense lesions were present in 60% and 65% of patients in BEV/IRI arm, while 57% and 63% were found in the TMZ arm, respectively. Double positive lesions were found in 37% of BEV/IRI patients and in 39% of TMZ patients. Neither the presence of T1-hyperintense, diffusion-restricted lesions, nor double positive lesions were associated with improved survival.<br />Conclusions: Baseline T1-hyperintense and diffusion-restricted lesions are not suitable to predict progression-free or overall survival of patients treated with bevacizumab/irinotecan or temozolomide.
- Subjects :
- Adult
Aged
Bevacizumab administration & dosage
Brain Neoplasms drug therapy
Brain Neoplasms pathology
Camptothecin administration & dosage
Dacarbazine administration & dosage
Female
Follow-Up Studies
Glioblastoma drug therapy
Glioblastoma pathology
Humans
Irinotecan administration & dosage
Male
Middle Aged
Prognosis
Survival Rate
Temozolomide administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Brain Neoplasms mortality
Glioblastoma mortality
Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7373
- Volume :
- 144
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neuro-oncology
- Publication Type :
- Academic Journal
- Accession number :
- 31325144
- Full Text :
- https://doi.org/10.1007/s11060-019-03246-4