Back to Search
Start Over
Pouchitis in pediatric ulcerative colitis: A multicenter study on behalf of Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2019 Nov; Vol. 51 (11), pp. 1551-1556. Date of Electronic Publication: 2019 Jul 16. - Publication Year :
- 2019
-
Abstract
- Background: Data on the epidemiology and risk factors for pouchitis following restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) in pediatric patients with ulcerative colitis (UC) are scarce.<br />Aims: To determine incidence, risk factors and clinical outcome of pouchitis following IPAA in children.<br />Methods: This multicenter, retrospective cohort study, included all pediatric UC patients who underwent colectomy and IPAA from January 2010 to December 2016.<br />Results: Eighty-five patients were enrolled. During a median post-surgical period of 24.8 (range: 1.0-72.0) months following IPAA, 38 (44.7%) patients developed pouchitis, including 6 (15.8%) who developed chronic pouchitis. Kaplan-Meier survival estimates of the cumulative probability for pouchitis were 14.6% at 1 year and 27.3% and 51.5% at 2 and 5 years, respectively. Multiple Cox regression model showed that older age at colectomy (hazard ratio, HR: 0.89, p = 0.008) was a protective factor, whereas chronic active colitis as indication for surgery (HR: 4.45, p < 0.001), and a 3-stage IPAA (HR: 2.86, p = 0.028) increased the risk for pouchitis.<br />Conclusions: Long-term risk for pouchitis is significantly high in pediatric-onset UC after IPAA. Younger age at colectomy, chronic active colitis as indication for surgery and 3-stage IPAA may increase the risk for pouchitis.<br /> (Copyright © 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Child
Female
Humans
Incidence
Italy epidemiology
Kaplan-Meier Estimate
Male
Postoperative Complications etiology
Pouchitis etiology
Proportional Hazards Models
Retrospective Studies
Risk Factors
Severity of Illness Index
Colitis, Ulcerative surgery
Postoperative Complications epidemiology
Pouchitis epidemiology
Proctocolectomy, Restorative adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 51
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 31324473
- Full Text :
- https://doi.org/10.1016/j.dld.2019.06.023