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Prognostic factors and nomogram for survival prediction in patients with primary pulmonary lymphoma: a SEER population-based study.
- Source :
-
Leukemia & lymphoma [Leuk Lymphoma] 2019 Dec; Vol. 60 (14), pp. 3406-3416. Date of Electronic Publication: 2019 Jul 19. - Publication Year :
- 2019
-
Abstract
- Primary pulmonary lymphomas (PPLs) are rare lymphoproliferative malignancies arising from the lungs. The prognostic factors and optimal management of PPL have not been clearly defined due to its rarity. This study sought to characterize the significant prognostic factors and develop a validated nomogram for individualized prediction of survival outcomes in patients with PPL. A total of 2325 patients diagnosed with PPL between 1983 and 2010 were identified using the Surveillance, Epidemiology, and End Results (SEER) database. Older age at diagnosis, males, Hispanic race, non-marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue histology, Ann Arbor stage IV were significantly associated with worse OS on multivariable analysis. All treatment modalities, including chemotherapy, surgery, and radiotherapy were independent predictors of survival on univariable analysis. The nomogram built demonstrated good discriminative ability and calibration, with the C-index of 0.690 and 0.730 in the training and validation cohorts, respectively.
- Subjects :
- Aged
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Lung Neoplasms pathology
Lung Neoplasms therapy
Lymphoma, B-Cell, Marginal Zone pathology
Lymphoma, B-Cell, Marginal Zone therapy
Lymphoma, Large B-Cell, Diffuse pathology
Lymphoma, Large B-Cell, Diffuse therapy
Male
Middle Aged
Prognosis
Retrospective Studies
Survival Rate
Lung Neoplasms mortality
Lymphoma, B-Cell, Marginal Zone mortality
Lymphoma, Large B-Cell, Diffuse mortality
Nomograms
SEER Program
Subjects
Details
- Language :
- English
- ISSN :
- 1029-2403
- Volume :
- 60
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Leukemia & lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 31322026
- Full Text :
- https://doi.org/10.1080/10428194.2019.1633636