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Cinnamon attenuates adiposity and affects the expression of metabolic genes in Diet-Induced obesity model of zebrafish.
- Source :
-
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2019 Dec; Vol. 47 (1), pp. 2930-2939. - Publication Year :
- 2019
-
Abstract
- The prevalence of obesity is increasing at an alarming rate worldwide with about 30% of the world population classified as obese. Obese body structure results when energy intake exceeds energy expenditure in an individual. Increase in the consumption of high-energy eatables, in the context of portion and energy provided, has resulted in obese populations which is becoming the leading cause of metabolic disorders related to morbidity. The obesity-related comorbidity is an enormous liability on health services and will affect measures taken in tackling the increasing obesity rate. Prevention of an obese phenotype is the most suitable long-term strategy. Another approach towards the treatment of obesity is weight management through phytotherapeutics. In this study, we explored the anti-obesity effects of Cinnamon ( Cinnamomum zeylanicum ) in adult male zebrafish. Through BMI measurements, blood glucose level analyses, serum triglyceride analyses, Oil Red O staining as well as quantitative Real Time-PCR, the ability of cinnamon to reduce metabolic disorders associated with obesity is investigated for the first time in a zebrafish model. Our studies indicate that cinnamon ameliorates the genotypic and phonotypic characteristics associated with obesity through lowering of BMI, blood glucose, triglyceride levels, lipid levels in the liver and through gene modulation.
- Subjects :
- Animals
Body Mass Index
Body Size drug effects
Body Weight drug effects
Disease Models, Animal
Liver drug effects
Liver pathology
Obesity etiology
Obesity genetics
Triglycerides blood
Zebrafish
Adiposity drug effects
Blood Glucose metabolism
Cinnamomum zeylanicum chemistry
Diet adverse effects
Gene Expression Regulation drug effects
Obesity metabolism
Obesity pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2169-141X
- Volume :
- 47
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Artificial cells, nanomedicine, and biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 31317780
- Full Text :
- https://doi.org/10.1080/21691401.2019.1641509