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A multi-centre evaluation of malignant odontogenic tumours in Nigeria.
- Source :
-
The Pan African medical journal [Pan Afr Med J] 2019 May 10; Vol. 33, pp. 18. Date of Electronic Publication: 2019 May 10 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Introduction: odontogenic tumors originate from neoplastic transformation of the remnants of tooth forming apparatus. There are varying degrees of inductive interactions between odontogenic ectomesenchyme and epithelium during odontogenesis, leading to lesions that vary from benign to malignant. Malignant odontogenic tumours (MOTs) are very rare and are classified according to embryonic tissue of origin. Recently, there has been a few changes to the classification of MOTs according to the World Health Organization's (WHO) classification in 2017. This study aims to evaluate and reclassify MOTs, using a multi-centre approach in some major tertiary dental hospitals in Nigeria.<br />Methods: this study reviewed the clinicopathological data on 63 cases of MOT diagnosed over 25 years in five major tertiary dental hospitals in Nigeria. All MOT cases were reclassified according to the recent revision to the 2017 WHO classification of odontogenic tumours.<br />Results: from a total of 10,446 biopsies of oral and jaw lesions seen at the 5 study centres over the 25-year study period, 2199 (21.05%) cases were found to be odontogenic tumours (OTs), of which 63 were MOT. MOTs constituted 0.60% of the total biopsy cases and 2.86% of OTs. Odontogenic carcinomas presented with a mean age higher than odontogenic sarcomas. According to our 2017 WHO reclassification of MOTs, odontogenic carcinomas, ameloblastic carcinomas and primary intraosseous carcinomas were found to be the top three lesions, respectively. Carcinosarcomas were found to be extremely rare.<br />Conclusion: using a multi-centre approach is a robust way to reduce diagnostic challenges associated with rare maxillofacial lesions such as MOTs.<br />Competing Interests: The authors declare no competing interests.
- Subjects :
- Adolescent
Adult
Age Factors
Aged
Ameloblastoma diagnosis
Ameloblastoma pathology
Biopsy methods
Carcinosarcoma diagnosis
Carcinosarcoma pathology
Child
Child, Preschool
Female
Humans
Jaw Neoplasms diagnosis
Jaw Neoplasms pathology
Male
Middle Aged
Nigeria epidemiology
Odontogenic Tumors diagnosis
Odontogenic Tumors pathology
Retrospective Studies
Young Adult
Ameloblastoma epidemiology
Carcinosarcoma epidemiology
Jaw Neoplasms epidemiology
Odontogenic Tumors epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1937-8688
- Volume :
- 33
- Database :
- MEDLINE
- Journal :
- The Pan African medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 31312334
- Full Text :
- https://doi.org/10.11604/pamj.2019.33.18.16179