Arsenic exposure during prepuberty alters prostate maturation in pubescent rats.

Authors :: Aquino AM
Salata GC
Pinho CF
de Freitas ATAG
Périco LL
de Lion Siervo GEM
Mendes LO
Da Cunha De Medeiros P
Justulin LA
Fernandes GSA
Perobelli JE
Scarano WR
Source :: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2019 Oct; Vol. 89, pp. 136-144. Date of Electronic Publication: 2019 Jul 13.
Publication Year :: 2019
Abstract: Arsenic is a widely dispersed chemical compound in the environment and has been associated with the development of some diseases and different types of cancer. Little is known about the action of arsenic compounds on prostate development during prepuberty and puberty. This study evaluated prostate morphophysiology after sodium arsenite exposure during prepubertal period in rats. Male Wistar rats at PND23 were randomly distributed into three experimental groups (n = 10/group). The Ctrl group (filtered drinking water); As1 group (0.01 mg/L of NaAsO <subscript>2</subscript> ); As2 group (10.0 mg/L of NaAsO <subscript>2</subscript> ) that received the diluted solution in drinking water from PND23 to PND53. Histological and molecular analyzes showed developmental delay in the As1 group and important morphophysiological alterations in As2 group. The results showed that exposure to NaAsO2 during prepuberty compromised structural and functional maturation of the prostate in pubertal rats at both doses evaluated in this study.<br /> (Copyright © 2019. Published by Elsevier Inc.)

Subjects :: Animals
Antioxidants metabolism
Collagen metabolism
Lipid Peroxidation drug effects
Male
Prostate growth & development
Prostate metabolism
Prostate pathology
Rats
Rats, Wistar
Testosterone blood
Aging drug effects
Arsenites toxicity
Environmental Pollutants toxicity
Prostate drug effects
Sexual Maturation drug effects
Sodium Compounds toxicity

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