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Autoimmune haemolytic anaemia in pancreatic adenocarcinoma: a potential paraneoplastic presentation.
- Source :
-
BMJ case reports [BMJ Case Rep] 2019 Jul 15; Vol. 12 (7). Date of Electronic Publication: 2019 Jul 15. - Publication Year :
- 2019
-
Abstract
- While autoimmune haemolytic anaemia (AIHA) is a well-known paraneoplastic syndrome in haematological malignancies, it has been described far less in solid tumours. We hereby report the case of a 61-year-old male patient presenting AIHA related to pancreatic cancer. Investigations excluded infectious, autoimmune and toxic causes of AIHA. CT of the abdomen highlighted the presence of hypodense, infiltrating mass of the tail of the pancreas measuring 70×37×36 mm, compatible with pancreas neoplasm. Histological examination of two associated nodular lesions of the liver showed metastasis of pancreatic adenocarcinoma. The patient was started on corticosteroid without improvement of haemoglobin. Palliative chemotherapy was initiated; this led to significant improvement in haemoglobin comforting our diagnosis. This case illustrates the rare association between AIHA and pancreatic cancer. However, such association cannot be considered before excluding other, more frequent, aetiologies.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Adenocarcinoma drug therapy
Anticoagulants therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Heparin, Low-Molecular-Weight therapeutic use
Humans
Male
Middle Aged
Pancreatic Neoplasms drug therapy
Paraneoplastic Syndromes drug therapy
Treatment Outcome
Venous Thrombosis drug therapy
Venous Thrombosis etiology
Adenocarcinoma complications
Anemia, Hemolytic, Autoimmune etiology
Pancreatic Neoplasms complications
Paraneoplastic Syndromes complications
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 12
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 31308189
- Full Text :
- https://doi.org/10.1136/bcr-2019-229807