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Reagent Controlled Direct Dehydrative Glycosylation with 2-Deoxy Sugars: Construction of the Saquayamycin Z Pentasaccharide.
- Source :
-
Organic letters [Org Lett] 2019 Aug 02; Vol. 21 (15), pp. 5922-5927. Date of Electronic Publication: 2019 Jul 15. - Publication Year :
- 2019
-
Abstract
- The first synthesis of the pentasaccharide fragment of the angucycline antibiotic saquayamycin Z is described. By using our sulfonyl chloride mediated reagent controlled dehydrative glycosylation, we are able to assemble the glycosidic linkages with high levels of anomeric selectivity. The total synthesis was completed in 25 total steps, and in 2.5% overall yield with a longest linear sequence of 15 steps.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 21
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 31305082
- Full Text :
- https://doi.org/10.1021/acs.orglett.9b02056